Mouse Vrk2 Antibody (C-term)

APR17454G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR17454G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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Mouse Vrk2 Antibody (C-term)

品牌	Leading Biology	貨號	APR17454G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Mouse Vrk2 antibody (C-term).
分子量	58119 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Endoplasmic reticulum membrane; Single-pass type IV membrane protein. Mitochondrion membrane; Single-pass type IV membrane protein
宿主	Rabbit
種屬反應(yīng)性	Mouse
免疫原	354-381 aa
靶點(diǎn)	This Mouse Vrk2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 354-381 amino acids from the C-terminal region of mouse Vrk2.
亞型	Rabbit Ig
基因ID	69922
UniProt ID	Q8BN21
功能	Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates histone H3. Phosphorylates 'Thr-18' of p53/TP53, and thereby increases its stability and activity. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. May also phosphorylate MAPK8IP1. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevant (By similarity).
總結(jié)	Probable serine/threonine kinase (By similarity).
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Serine/threonine-protein kinase VRK2, Vaccinia-related kinase 2, Vrk2
圖像	Mouse Vrk2 Antibody (C-term) (Cat. APR17454G) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the Vrk2 antibody detected the Vrk2 protein (arrow).
說明書	Product Datasheet Protocol
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