全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR13526G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SPRY2 antibody (N-term).
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分子量 |
34688 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm, cytoskeleton. Cell projection, ruffle membrane. Note=Associated with microtubules in unstimulated cells but is translocated to the membrane ruffles in cells stimulated ith EGF (epidermal growth factor)
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse
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免疫原 |
6-35 aa
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靶點(diǎn) |
This SPRY2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-35 amino acids from the N-terminal region of human SPRY2.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.
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總結(jié) |
This gene encodes a protein belonging to the sproutyfamily. The encoded protein contains a carboxyl-terminalcysteine-rich domain essential for the inhibitory activity onreceptor tyrosine kinase signaling proteins and is required forgrowth factor stimulated translocation of the protein to membraneruffles. In primary dermal endothelial cells this gene istransiently upregulated in response to fibroblast growth factortwo. This protein is indirectly involved in the non-cell autonomousinhibitory effect on fibroblast growth factor two signaling. Theprotein interacts with Cas-Br-M (murine) ectropic retroviraltransforming sequence, and can function as a bimodal regulator ofepidermal growth factor receptor/mitogen-activated protein kinasesignaling. This protein may play a role in alveoli branching duringlung development as shown by a similar mouse protein. [provided byRefSeq].
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Protein sprouty homolog 2, Spry-2, SPRY2
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圖像 |
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說明書 |
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數(shù)量 |
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