HIRA Antibody (N-term)

APR16638G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR16638G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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HIRA Antibody (N-term)

品牌	Leading Biology	貨號	APR16638G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HIRA antibody (N-term).
分子量	111835 Da
細胞定位	Antigen Cellular Localization: Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence
宿主	Rabbit
種屬反應性	Human
免疫原	32-61 aa
靶點	This HIRA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 32-61 amino acids from the N-terminal region of human HIRA.
亞型	Rabbit Ig
通用名	DGCR1, HIR, TUPLE1
基因ID	7290
UniProt ID	P54198
功能	Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit.
總結(jié)	This gene encodes a histone chaperone that preferentiallyplaces the variant histone H3.3 in nucleosomes. Orthologs of thisgene in yeast, flies, and plants are necessary for the formation oftranscriptionally silent heterochomatin. This gene plays animportant role in the formation of the senescence-associatedheterochromatin foci. These foci likely mediate the irreversiblecell cycle changes that occur in senescent cells. It is consideredthe primary candidate gene in some haploinsufficiency syndromessuch as DiGeorge syndrome, and insufficient production of the genemay disrupt normal embryonic development.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, E
稀釋方法	WB~~1:1000
別名	Protein HIRA, TUP1-like enhancer of split protein 1, HIRA, DGCR1, HIR, TUPLE1
圖像	Anti-HIRA Antibody (N-term) at 1:1000 dilution + Hela whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 112 kDa Blocking/Dilution buffer: 5% NFDM/TBST. HIRA Antibody (N-term) (Cat. APR16638G) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the HIRA antibody detected the HIRA protein (arrow).
說明書	Product Datasheet Protocol
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