HNRNPA1 Antibody (C-term)

APR11135G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR11135G		100 μl / ￥4950

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HNRNPA1 Antibody (C-term)

品牌	Leading Biology	貨號	APR11135G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality HNRNPA1 antibody (C-term).
分子量	38747 Da
細胞定位	Antigen Cellular Localization: Nucleus. Cytoplasm. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes. In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	266-294 aa
靶點	This HNRNPA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-294 amino acids from the C-terminal region of human HNRNPA1.
亞型	Rabbit Ig
通用名	HNRPA1
基因ID	3178
UniProt ID	P09651
功能	Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection. May play a role in HCV RNA replication.
總結(jié)	This gene belongs to the A/B subfamily of ubiquitouslyexpressed heterogeneous nuclear ribonucleoproteins (hnRNPs). ThehnRNPs are RNA binding proteins and they complex with heterogeneousnuclear RNA (hnRNA). These proteins are associated with pre-mRNAsin the nucleus and appear to influence pre-mRNA processing andother aspects of mRNA metabolism and transport. While all of thehnRNPs are present in the nucleus, some seem to shuttle between thenucleus and the cytoplasm. The hnRNP proteins have distinct nucleicacid binding properties. The protein encoded by this gene has tworepeats of quasi-RRM domains that bind to RNAs. It is one of themost abundant core proteins of hnRNP complexes and it is localizedto the nucleoplasm. This protein, along with other hnRNP proteins,is exported from the nucleus, probably bound to mRNA, and isimmediately re-imported. Its M9 domain acts as both a nuclearlocalization and nuclear export signal. The encoded protein isinvolved in the packaging of pre-mRNA into hnRNP particles,transport of poly A+ mRNA from the nucleus to the cytoplasm, andmay modulate splice site selection. It is also thought have aprimary role in the formation of specific myometrial proteinspecies in parturition. Multiple alternatively spliced transcriptvariants have been found for this gene but only two transcripts arefully described. These variants have multiple alternativetranscription initiation sites and multiple polyA sites. [providedby RefSeq].
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Heterogeneous nuclear ribonucleoprotein A1, hnRNP A1, Helix-destabilizing protein, Single-strand RNA-binding protein, hnRNP core protein A1, Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed, HNRNPA1, HNRPA1
圖像	All lanes : Anti-HNRNPA1 Antibody (C-term) at 1:1000 dilution Lane 1: Hela whole cell lysates Lane 2: HepG2 whole cell lysates Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 39 kDa Blocking/Dilution buffer: 5% NFDM/TBST. HNRNPA1 Antibody (C-term) (Cat. APR11135G) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the HNRNPA1 antibody detected the HNRNPA1 protein (arrow). Western blot analysis of HNRNPA1 (arrow) using rabbit polyclonal HNRNPA1 Antibody (C-term) (Cat. APR11135G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the HNRNPA1 gene.
說明書	Product Datasheet Protocol
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