全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM05993G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality GRM7 antibody (N-term).
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分子量 |
102251 Da
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細胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein.
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宿主 |
Rabbit
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種屬反應性 |
Human
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免疫原 |
240-269 aa
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靶點 |
This GRM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 240-269 amino acids from the N-terminal region of human GRM7.
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亞型 |
Rabbit Ig
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通用名 |
GPRC1G, MGLUR7
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基因ID |
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UniProt ID |
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功能 |
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
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總結 |
L-glutamate is the major excitatory neurotransmitter inthe central nervous system, and it activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmissionis involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropicglutamate receptors are a family of G protein-coupled receptorsthat have been divided into three groups on the basis of sequencehomology, putative signal transduction mechanisms, andpharmacologic properties. Group I includes GRM1 and GRM5, and thesereceptors have been shown to activate phospholipase C. Group IIincludes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibitionof the cyclic AMP cascade but differ in their agonistselectivities. Multiple transcript variants encoding differentisoforms have been found for this gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Metabotropic glutamate receptor 7, mGluR7, GRM7, GPRC1G, MGLUR7
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圖像 |
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說明書 |
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數(shù)量 |
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