SNX2 Antibody (C-term)

AMM07913G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM07913G		100 μl / ￥4950

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SNX2 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	AMM07913G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SNX2 antibody (C-term).
分子量	58471 Da
細(xì)胞定位	Antigen Cellular Localization: Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium Note=Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalized with F-actin at the leading edge of lamellipodia in cells in a KALRN-dependent manner (PubMed:20604901).
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	457-485 aa
靶點(diǎn)	This SNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 457-485 amino acids from the C-terminal region of human SNX2.
亞型	Rabbit Ig
基因ID	6643
UniProt ID	O60749
功能	Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3- phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:16179610). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:17101778). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Required for retrograde endosome-to-TGN transport of TGN38 (PubMed:20138391). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901).
總結(jié)	This gene encodes a member of the sorting nexin family.Members of this family contain a phox (PX) domain, which is aphosphoinositide binding domain, and are involved in intracellulartrafficking. This protein associates with formin-binding protein17, but its function is unknown. This protein may form oligomericcomplexes with family members.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Sorting nexin-2, Transformation-related gene 9 protein, TRG-9, SNX2
圖像	SNX2 Antibody (C-term) (Cat. AMM07913G) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the SNX2 antibody detected the SNX2 protein (arrow).
說(shuō)明書	Product Datasheet Protocol
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