全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
AMM07408G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PTPRE antibody (N-term).
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分子量 |
80642 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Isoform 1: Cell membrane; Single-pass type I membrane protein Isoform 3: Cytoplasm.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
134-163 aa
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靶點 |
This PTPRE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 134-163 amino acids from the N-terminal region of human PTPRE.
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亞型 |
Rabbit Ig
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基因ID |
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UniProt ID |
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功能 |
Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity).
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總結(jié) |
The protein encoded by this gene is a member of theprotein tyrosine phosphatase (PTP) family. PTPs are known to besignaling molecules that regulate a variety of cellular processesincluding cell growth, differentiation, mitotic cycle, andoncogenic transformation. Two alternatively spliced transcriptvariants of this gene have been reported, one of which encodes areceptor-type PTP that possesses a short extracellular domain, asingle transmembrane region, and two tandem intracytoplasmiccatalytic domains; Another one encodes a PTP that contains adistinct hydrophilic N-terminus, and thus represents anonreceptor-type isoform of this PTP. Studies of the similar genein mice suggested the regulatory roles of this PTP in RAS relatedsignal transduction pathways, cytokines induced SATA signaling, aswell as the activation of voltage-gated K+ channels. [provided byRefSeq].
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:10~50
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別名 |
Receptor-type tyrosine-protein phosphatase epsilon, Protein-tyrosine phosphatase epsilon, R-PTP-epsilon, PTPRE
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圖像 |
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說明書 |
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數(shù)量 |
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