Nucleostemin (GNL3) Antibody (C-term)

AMM06861G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM06861G		100 μl / ￥4950

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Nucleostemin (GNL3) Antibody (C-term)

品牌	Leading Biology	貨號	AMM06861G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Nucleostemin (GNL3) antibody (C-term).
分子量	61993 Da
細胞定位	Antigen Cellular Localization: Nucleus. Nucleus, nucleolus. Note=Shuttles between the nucleus and nucleolus
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	458-487 aa
靶點	This Nucleostemin (GNL3) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-487 amino acids from the C-terminal region of human Nucleostemin (GNL3).
亞型	Rabbit Ig
通用名	E2IG3, NS
基因ID	26354
UniProt ID	Q9BVP2
功能	May be required to maintain the proliferative capacity of stem cells. Stabilizes MDM2 by preventing its ubiquitination, and hence proteasomal degradation (By similarity).
總結(jié)	GNL3 is found in the nucleoli of embryonic stem cells, adult CNS stem cells, primitive cells in the bone marrow and cancer cells. It is not in the differentiated cells of most adult tissues. It has been suggested to play a role in controlling the cell-cycle progression in stem cells and cancer cells, and may be required to maintain the proliferative capacity of stem cells.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50
別名	Guanine nucleotide-binding protein-like 3, E2-induced gene 3 protein, Novel nucleolar protein 47, NNP47, Nucleolar GTP-binding protein 3, Nucleostemin, GNL3, E2IG3, NS
圖像	Western blot analysis of GNL3 Antibody (C-term) (Cat. AMM06861G) in HL60 cell line lysates (35ug/lane). GNL3 (arrow) was detected using the purified Pab. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with GNL3 antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
說明書	Product Datasheet Protocol
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