全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR10012G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SLC22A1 antibody (C-term).
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分子量 |
61154 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Basolateral cell membrane; Multi-pass membrane protein
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
511-539 aa
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靶點(diǎn) |
This SLC22A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 511-539 amino acids from the C-terminal region of human SLC22A1.
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亞型 |
Rabbit Ig
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通用名 |
1-Oct
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基因ID |
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UniProt ID |
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功能 |
Translocates a broad array of organic cations with various structures and molecular weights including the model compounds 1-methyl-4-phenylpyridinium (MPP), tetraethylammonium (TEA), N-1-methylnicotinamide (NMN), 4-(4-(dimethylamino)styryl)- N-methylpyridinium (ASP), the endogenous compounds choline, guanidine, histamine, epinephrine, adrenaline, noradrenaline and dopamine, and the drugs quinine, and metformin. The transport of organic cations is inhibited by a broad array of compounds like tetramethylammonium (TMA), cocaine, lidocaine, NMDA receptor antagonists, atropine, prazosin, cimetidine, TEA and NMN, guanidine, cimetidine, choline, procainamide, quinine, tetrabutylammonium, and tetrapentylammonium. Translocates organic cations in an electrogenic and pH-independent manner. Translocates organic cations across the plasma membrane in both directions. Transports the polyamines spermine and spermidine. Transports pramipexole across the basolateral membrane of the proximal tubular epithelial cells. The choline transport is activated by MMTS. Regulated by various intracellular signaling pathways including inhibition by protein kinase A activation, and endogenously activation by the calmodulin complex, the calmodulin- dependent kinase II and LCK tyrosine kinase.
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總結(jié) |
Polyspecific organic cation transporters in the liver,kidney, intestine, and other organs are critical for elimination ofmany endogenous small organic cations as well as a wide array ofdrugs and environmental toxins. This gene is one of three similarcation transporter genes located in a cluster on chromosome 6. Theencoded protein contains twelve putative transmembrane domains andis a plasma integral membrane protein. Two transcript variantsencoding two different isoforms have been found for this gene, butonly the longer variant encodes a functional transporter. [providedby RefSeq].
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:10~50
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別名 |
Solute carrier family 22 member 1, Organic cation transporter 1, hOCT1, SLC22A1, OCT1
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圖像 |
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說明書 |
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數(shù)量 |
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