ULK3 Antibody (C-term)

AMM08429G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM08429G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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ULK3 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	AMM08429G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality ULK3 antibody (C-term).
分子量	53444 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Note=Localizes to pre-autophagosomal structure during cellular senescence
宿主	Rabbit
種屬反應(yīng)性	Mouse
免疫原	347-375 aa
靶點(diǎn)	This ULK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-375 amino acids from the C-terminal region of human ULK3.
亞型	Rabbit Ig
基因ID	25989
UniProt ID	Q6PHR2
功能	Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
總結(jié)	Serine/threonine protein kinase which enhances GLI1 and GLI2 transcriptional activity and consequently positively regulates GLI-dependent SHH signaling. May exert this function by promoting GLI1 nuclear localization. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Serine/threonine-protein kinase ULK3, Unc-51-like kinase 3, ULK3
圖像	ULK3 Antibody (C-term) (Cat. AMM08429G) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the ULK3 antibody detected the ULK3 protein (arrow).
說明書	Product Datasheet Protocol
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