全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
AMR09418G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality POFUT2 antibody (Center).
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分子量 |
49976 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Endoplasmic reticulum. Golgi apparatus. Note=Mainly located in the endoplasmic reticulum
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
228-257 aa
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靶點(diǎn) |
This POFUT2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 228-257 amino acids from the Central region of human POFUT2.
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亞型 |
Rabbit Ig
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通用名 |
C21orf80, FUT13, KIAA0958
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基因ID |
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UniProt ID |
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功能 |
Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13.
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總結(jié) |
Fucose is typically found as a terminal modification ofbranched chain glycoconjugates, but it also exists in directO-linkage to serine or threonine residues within cystine knotmotifs in epidermal growth factor (EGF; MIM 131530)-like repeats orthrombospondin (THBS; see MIM 188060) type-1 repeats. POFUT2 is anO-fucosyltransferase that use THBS type-1 repeats as substrates(Luo et al., 2006 [PubMed 16464857]).
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:10~50
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別名 |
GDP-fucose protein O-fucosyltransferase 2, Peptide-O-fucosyltransferase 2, O-FucT-2, POFUT2, C21orf80, FUT13, KIAA0958
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圖像 |
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說明書 |
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數(shù)量 |
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