GPS1 Antibody (Center)

APR12241G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR12241G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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GPS1 Antibody (Center)

品牌	Leading Biology	貨號(hào)	APR12241G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GPS1 antibody (Center).
分子量	55537 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Nucleus
宿主	Rabbit
種屬反應(yīng)性	Mouse
免疫原	141-170 aa
靶點(diǎn)	This GPS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-170 amino acids from the Central region of human GPS1.
亞型	Rabbit Ig
通用名	COPS1, CSN1
基因ID	2873
UniProt ID	Q13098
功能	Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
總結(jié)	This gene is known to suppress G-protein andmitogen-activated signal transduction in mammalian cells. Theencoded protein shares significant similarity with ArabidopsisFUS6, which is a regulator of light-mediated signal transduction inplant cells. Two alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	COP9 signalosome complex subunit 1, SGN1, Signalosome subunit 1, G protein pathway suppressor 1, GPS-1, JAB1-containing signalosome subunit 1, Protein MFH, GPS1, COPS1, CSN1
圖像	GPS1 Antibody (Center) (Cat. APR12241G) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the GPS1 antibody detected the GPS1 protein (arrow).
說明書	Product Datasheet Protocol
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