PSTPIP1 Antibody (N-term)

AMM07370G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM07370G		100 μl / ￥4950

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PSTPIP1 Antibody (N-term)

品牌	Leading Biology	貨號(hào)	AMM07370G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PSTPIP1 antibody (N-term).
分子量	47591 Da
細(xì)胞定位	Antigen Cellular Localization: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cell projection, uropodium. Cytoplasm, perinuclear region. Cleavage furrow. Note=During interphase, colocalizes with F- actin in the cortical cytoskeleton, lamellipodia, and stress fibers. In dividing cells, colocalizes with the F-actin rich cytokinetic cleavage furrow. Colocalized with WAS to filamentous structures within the cytoplasm. Colocalized with PTPN12 in the cytoplasm and the perinuclear region. Colocalized with CD2AP and WAS in the actin cytoskeleton. Colocalized with CD2, CD2AP and WAS at the site of T-cell:APC contact (By similarity). In monocytes, forms a branched filamentous network in the cytoplasm. In migrating neutrophils, localizes most strongly to the trailing edge of the uropod where it colocalizes with PIP5K1C. In transfected cells, forms relatively straight filaments radiating out from the nucleus. Colocalizes with MEFV, particularly at the branch point of filaments. Filament formation requires an intact tubulin cytoskeleton.
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	89-118 aa
靶點(diǎn)	This PSTPIP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-118 amino acids from the N-terminal region of human PSTPIP1.
亞型	Rabbit Ig
通用名	CD2BP1
基因ID	9051
UniProt ID	O43586
功能	Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation (By similarity). Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.
總結(jié)	The protein encoded by this gene binds to the cytoplasmictail of CD2, an effector of T cell activation and adhesion,negatively affecting CD2-triggered T cell activation. The encodedprotein appears to be a scaffold protein and a regulator of theactin cytoskeleton. It has also been shown to bind ABL1, PTPN18,WAS, CD2AP, and PTPN12. Mutations in this gene are a cause of PAPAsyndrome.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, FC, E
稀釋方法	WB~~1:1000 FC~~1:10~50
別名	Proline-serine-threonine phosphatase-interacting protein 1, PEST phosphatase-interacting protein 1, CD2-binding protein 1, H-PIP, PSTPIP1, CD2BP1
圖像	PSTPIP1 Antibody (N-term) (Cat. AMM07370G) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PSTPIP1 antibody detected the PSTPIP1 protein (arrow). PSTPIP1 Antibody (N-term) (Cat. AMM07370G) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
說(shuō)明書	Product Datasheet Protocol
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