品牌 |
Leading Biology | 貨號 |
AMM06129G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality KCNJ4 antibody (N-term).
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分子量 |
49500 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 famaly members and KCNJ4 internalization
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
1-30 aa
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靶點 |
This KCNJ4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNJ4.
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亞型 |
Rabbit Ig
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通用名 |
IRK3
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基因ID |
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UniProt ID |
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功能 |
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity).
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總結(jié) |
Several different potassium channels are known to beinvolved with electrical signaling in the nervous system. One classis activated by depolarization whereas a second class is not. Thelatter are referred to as inwardly rectifying K+ channels, and theyhave a greater tendency to allow potassium to flow into the cellrather than out of it. This asymmetry in potassium ion conductanceplays a key role in the excitability of muscle cells and neurons.The protein encoded by this gene is an integral membrane proteinand member of the inward rectifier potassium channel family. Theencoded protein has a small unitary conductance compared to othermembers of this protein family. Two transcript variants encodingthe same protein have been found for this gene. [provided byRefSeq].
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, E
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稀釋方法 |
WB~~1:1000
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別名 |
Inward rectifier potassium channel 4, HIRK2, HRK1, Hippocampal inward rectifier, HIR, Inward rectifier K(+) channel Kir23, IRK-3, Potassium channel, inwardly rectifying subfamily J member 4, KCNJ4, IRK3
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圖像 |
KCNJ4 Antibody (N-term) (Cat. AMM06129G) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the KCNJ4 antibody detected the KCNJ4 protein (arrow). |
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說明書 |
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數(shù)量 |
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