全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APG02767G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CRFR1 antibody (Q103).
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分子量 |
50719 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein. Endosome. Note=Agonist-binding promotes endocytosis
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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免疫原 |
88-119 aa
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靶點(diǎn) |
This CRFR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 88-119 amino acids from human CRFR1.
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亞型 |
Rabbit Ig
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通用名 |
CRFR, CRFR1, CRHR
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基因ID |
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UniProt ID |
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功能 |
G-protein coupled receptor for CRH (corticotropin- releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.
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總結(jié) |
This gene encodes a G-protein coupled receptor that bindsneuropeptides of the corticotropin releasing hormone family thatare major regulators of the hypothalamic-pituitary-adrenal pathway.The encoded protein is essential for the activation of signaltransduction pathways that regulate diverse physiological processesincluding stress, reproduction, immune response and obesity.Alternative splicing results in multiple transcript variants.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, FC, E
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稀釋方法 |
WB~~1:1000
FC~~1:10~50
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別名 |
Corticotropin-releasing factor receptor 1, CRF-R-1, CRF-R1, CRFR-1, Corticotropin-releasing hormone receptor 1, CRH-R-1, CRH-R1, CRHR1, CRFR, CRFR1, CRHR
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圖像 |
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說明書 |
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數(shù)量 |
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