全部產品分類
品牌 |
Leading Biology | 貨號 |
APR17488G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality MUTED antibody (Center).
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分子量 |
21609 Da
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宿主 |
Rabbit
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種屬反應性 |
Human, Mouse
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免疫原 |
40-68 aa
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靶點 |
This MUTED antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 40-68 amino acids from the Central region of human MUTED.
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亞型 |
Rabbit Ig
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通用名 |
MUTED
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基因ID |
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UniProt ID |
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功能 |
Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking.
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總結 |
This gene encodes a component of BLOC-1 (biogenesis oflysosome-related organelles complex 1). Components of this complexare involved in the biogenesis of organelles such as melanosomesand platelet-dense granules. A mouse model for Hermansky-PudlakSyndrome is mutated in the murine version of this gene. Alternativesplicing results in multiple transcript variants. Read-throughtranscription exists between this gene and the upstream EEF1E1(eukaryotic translation elongation factor 1 epsilon 1) gene, aswell as with the downstream TXNDC5 (thioredoxin domain containing5) gene.
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形式 |
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC-P, E
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稀釋方法 |
WB~~1:1000
IHC-P~~1:50~100
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別名 |
Biogenesis of lysosome-related organelles complex 1 subunit 5, BLOC-1 subunit 5, Protein Muted homolog, BLOC1S5, MUTED
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圖像 |
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說明書 |
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數(shù)量 |
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