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當(dāng)前位置:首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > STIM1 Antibody (C-term)

STIM1 Antibody (C-term)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR10301G 100 μl / ¥4950

STIM1 Antibody (C-term)

品牌

Leading Biology

貨號(hào)

APR10301G

產(chǎn)品分類

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality STIM1 antibody (C-term).

分子量

77423 Da

細(xì)胞定位

Antigen Cellular Localization: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules

宿主

Rabbit

種屬反應(yīng)性

Human

免疫原

509-538 aa

靶點(diǎn)

This STIM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-538 amino acids from the C-terminal region of human STIM1.

亞型

Rabbit Ig

通用名

GOK

基因ID

UniProt ID

功能

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.

總結(jié)

This gene encodes a type 1 transmembrane protein thatmediates Ca2+ influx after depletion of intracellular Ca2+ storesby gating of store-operated Ca2+ influx channels (SOCs). It is oneof several genes located in the imprinted gene domain of 11p15.5,an important tumor-suppressor gene region. Alterations in thisregion have been associated with the Beckwith-Wiedemann syndrome,Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung,ovarian, and breast cancer. This gene may play a role inmalignancies and disease that involve this region, as well as earlyhematopoiesis, by mediating attachment to stromal cells. This geneis oriented in a head-to-tail configuration with the ribonucleotidereductase 1 gene (RRM1), with the 3' end of this gene situated 1.6kb from the 5' end of the RRM1 gene.

形式

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IHC-P, E

稀釋方法

WB~~1:1000 IHC-P~~1:50~100

別名

Stromal interaction molecule 1, STIM1, GOK

圖像

STIM1 Antibody (C-term) (Cat. APR10301G) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the STIM1 antibody detected the STIM1 protein (arrow).

STIM1 Antibody (C-term) (Cat. APR10301G) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the STIM1 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.

說(shuō)明書(shū)

數(shù)量

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