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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > UPF3A / RENT3A Antibody (internal region)品牌 |
Leading Biology | 貨號(hào) |
AMM08435G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality UPF3A / RENT3A antibody (internal region).
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分子量 |
54696 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Shuttling between the nucleus and the cytoplasm
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宿主 |
Goat
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亞型 |
IgG
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通用名 |
RENT3A, UPF3
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基因ID |
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UniProt ID |
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功能 |
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC) and serving as link between the EJC core and NMD machinery. Recruits UPF2 at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2- UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. However, UPF3A is shown to be only marginally active in NMD as compared to UPF3B. Binds spliced mRNA upstream of exon-exon junctions. In vitro, weakly stimulates translation.
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總結(jié) |
This antibody is expected to recognize both isoforms (NP_075387.1; NP_542418.1).
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形式 |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
E
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別名 |
Regulator of nonsense transcripts 3A, Nonsense mRNA reducing factor 3A, Up-frameshift suppressor 3 homolog A, hUpf3, UPF3A, RENT3A, UPF3
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說明書 |
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數(shù)量 |
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