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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > SPEN / SHARP Antibody (internal region)品牌 |
Leading Biology | 貨號(hào) |
AMM07955G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality SPEN / SHARP antibody (internal region).
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分子量 |
402248 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus. Note=Associates with chromatin
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宿主 |
Goat
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亞型 |
IgG
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通用名 |
KIAA0929, MINT, SHARP
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基因ID |
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UniProt ID |
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功能 |
May serve as a nuclear matrix platform that organizes and integrates transcriptional responses. In osteoblasts, supports transcription activation: synergizes with RUNX2 to enhance FGFR2- mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Has also been shown to be an essential corepressor protein, which probably regulates different key pathways such as the Notch pathway. Negative regulator of the Notch pathway via its interaction with RBPSUH, which prevents the association between NOTCH1 and RBPSUH, and therefore suppresses the transactivation activity of Notch signaling. Blocks the differentiation of precursor B-cells into marginal zone B-cells. Probably represses transcription via the recruitment of large complexes containing histone deacetylase proteins. May bind both to DNA and RNA.
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形式 |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
E
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別名 |
Msx2-interacting protein, SMART/HDAC1-associated repressor protein, SPEN homolog, SPEN, KIAA0929, MINT, SHARP
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說(shuō)明書(shū) |
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數(shù)量 |
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