TNIK Antibody (N-term)

AMM08578G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
AMM08578G		100 μl / ￥5450

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TNIK Antibody (N-term)

品牌	Leading Biology	貨號	AMM08578G
產品分類	Polyclonal Antibodies	研究領域
產品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TNIK antibody (N-term).
分子量	154943 Da
細胞定位	Antigen Cellular Localization: Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression
宿主	Rabbit
種屬反應性	Human, Mouse
免疫原	1-30 aa
靶點	This TNIK antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TNIK.
亞型	Rabbit Ig
通用名	KIAA0551
基因ID	23043
UniProt ID	Q9UKE5
功能	Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
總結	Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM]
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:50~100
別名	TRAF2 and NCK-interacting protein kinase, TNIK, KIAA0551
圖像	The anti-TNIK Pab (Cat. AMM08578G) is used in Western blot to detect TNIK in mouse brain tissue lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma. TNIK Antibody (M1) (Cat. AMM08578G) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the TNIK antibody detected the TNIK protein (arrow).
說明書	Product Datasheet Protocol
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