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當(dāng)前位置:首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > PIP5K3 Antibody (Center)

PIP5K3 Antibody (Center)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)
APR10846G 100 μl / ¥5450

PIP5K3 Antibody (Center)

品牌

Leading Biology

貨號(hào)

APR10846G

產(chǎn)品分類(lèi)

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality PIP5K3 antibody (Center).

分子量

237136 Da

細(xì)胞定位

Antigen Cellular Localization: Endosome membrane Note=Mainly associated with membranes of the late endocytic pathway

宿主

Rabbit

種屬反應(yīng)性

Human

免疫原

1531-1561 aa

靶點(diǎn)

This PIP5K3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1531-1561 amino acids from the Central region of human PIP5K3.

亞型

Rabbit Ig

通用名

KIAA0981, PIP5K3

基因ID

UniProt ID

功能

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the phosphorylation of phosphatidylinositol 3-phosphate on the fifth hydroxyl of the myo- inositol ring, to form phosphatidylinositol 3,5-bisphosphate. Required for endocytic-vacuolar pathway and nuclear migration. Plays a role in the biogenesis of endosome carrier vesicles (ECV)/ multivesicular bodies (MVB) transport intermediates from early endosomes.

總結(jié)

PIP5K3 belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. Signaling by phosphorylated species of phosphatidylinositol regulates diverse cellular processes, including membrane trafficking and cytoskeletal reorganization.

形式

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IHC-P, E

稀釋方法

WB~~1:1000 IHC-P~~1:50~100

別名

1-phosphatidylinositol 3-phosphate 5-kinase, Phosphatidylinositol 3-phosphate 5-kinase, FYVE finger-containing phosphoinositide kinase, PIKfyve, Phosphatidylinositol 3-phosphate 5-kinase type III, PIPkin-III, Type III PIP kinase, PIKFYVE, KIAA0981, PIP5K3

圖像

Western blot analysis of PIP5K3 (arrow) using rabbit polyclonal PIP5K3 Antibody (Center) (Cat. APR10846G). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the PIP5K3 gene (Lane 2) (Origene Technologies).

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

說(shuō)明書(shū)

數(shù)量

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