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當(dāng)前位置:首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > GJB2 Antibody (C-term)

GJB2 Antibody (C-term)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)
APR14112G 100 μl / ¥5450

GJB2 Antibody (C-term)

品牌

Leading Biology

貨號(hào)

APR14112G

產(chǎn)品分類(lèi)

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GJB2 antibody (C-term).

分子量

26215 Da

細(xì)胞定位

Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein. Cell junction, gap junction

宿主

Rabbit

種屬反應(yīng)性

Human, Mouse

免疫原

204-226 aa

靶點(diǎn)

This GJB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 204-226 amino acids from the C-terminal region of human GJB2.

亞型

Rabbit Ig

基因ID

UniProt ID

功能

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

總結(jié)

Gap junctions are conduits that allow the direct cell-to-cell passage of small cytoplasmic molecules, including ions, metabolic intermediates, and second messengers, and thereby mediate intercellular metabolic and electrical communication. Gap junction channels consist of connexin protein subunits, which are encoded by a multigene family. GJBs (gap-junction proteins or connexins) play crucial functional roles associated with these channels. Immunohistochemical staining of human cochlear cells demonstrated high levels of GJB2 expression. Mutations in GJB2 are associated with genetically derived hearing impairments, including autosomal recessive nonsyndromic deafness.

形式

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

儲(chǔ)存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IHC-P, E

稀釋方法

WB~~1:1000 IHC-P~~1:50~100

別名

Gap junction beta-2 protein, Connexin-26, Cx26, GJB2

圖像

Western blot analysis of hGJB2-C218.Connexin (Cat. APR14112G) in mouse brain tissue lysates (35ug/lane). GJB2 (arrow) was detected using the purified Pab.

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

說(shuō)明書(shū)

數(shù)量

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