TRPV1 Antibody (N-term)

APR14075G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR14075G		100 μl / ￥5450

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TRPV1 Antibody (N-term)

品牌	Leading Biology	貨號(hào)	APR14075G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality TRPV1 antibody (N-term).
分子量	94956 Da
細(xì)胞定位	Antigen Cellular Localization: Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein Cell projection, dendritic spine membrane; Multi- pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Mostly, but not exclusively expressed in postsynaptic dendritic spines.
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	124-153 aa
靶點(diǎn)	This TRPV1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 124-153 amino acids from the N-terminal region of human TRPV1.
亞型	Rabbit Ig
通用名	VR1
基因ID	7442
UniProt ID	Q8NER1
功能	Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Can be activated by endogenous compounds, including 12- hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis (By similarity). Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca(2+)-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH <6) directly activate the channel.
總結(jié)	Capsaicin, the main pungent ingredient in hot chilipeppers, elicits a sensation of burning pain by selectivelyactivating sensory neurons that convey information about noxiousstimuli to the central nervous system. The protein encoded by thisgene is a receptor for capsaicin and is a non-selective cationchannel that is structurally related to members of the TRP familyof ion channels. This receptor is also activated by increases intemperature in the noxious range, suggesting that it functions as atransducer of painful thermal stimuli in vivo. Four transcriptvariants encoding the same protein, but with different 5' UTRsequence, have been described for this gene.
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC-P, E
稀釋方法	WB~~1:1000 IHC-P~~1:10~50
別名	Transient receptor potential cation channel subfamily V member 1, TrpV1, Capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Vanilloid receptor 1, TRPV1, VR1
圖像	TRPV1 Antibody (N-term) (Cat. APR14075G) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the TRPV1 antibody detected the TRPV1 protein (arrow). TRPV1 Antibody (N-term) (Cat. APR14075G)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of TRPV1 Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
說明書	Product Datasheet Protocol
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