GRM8 Antibody (C-term)

AMM05994G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
AMM05994G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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GRM8 Antibody (C-term)

品牌	Leading Biology	貨號(hào)	AMM05994G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality GRM8 antibody (C-term).
分子量	101741 Da
細(xì)胞定位	Antigen Cellular Localization: Cell membrane; Multi-pass membrane protein.
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	855-884 aa
靶點(diǎn)	This GRM8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 855-884 amino acids from the C-terminal region of human GRM8.
亞型	Rabbit Ig
通用名	GPRC1H, MGLUR8
基因ID	2918
UniProt ID	O00222
功能	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
總結(jié)	L-glutamate is the major excitatory neurotransmitter inthe central nervous system and activates both ionotropic andmetabotropic glutamate receptors. Glutamatergic neurotransmissionis involved in most aspects of normal brain function and can beperturbed in many neuropathologic conditions. The metabotropicglutamate receptors are a family of G protein-coupled receptors,that have been divided into 3 groups on the basis of sequencehomology, putative signal transduction mechanisms, andpharmacologic properties. Group I includes GRM1 and GRM5 and thesereceptors have been shown to activate phospholipase C. Group IIincludes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibitionof the cyclic AMP cascade but differ in their agonistselectivities. Alternatively spliced transcript variants encodingdifferent isoforms have been described for this gene. [provided byRefSeq].
形式	Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, E
稀釋方法	WB~~1:1000
別名	Metabotropic glutamate receptor 8, mGluR8, GRM8, GPRC1H, MGLUR8
圖像	GRM8 Antibody (C-term) (Cat. AMM05994G) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the GRM8 antibody detected the GRM8 protein (arrow).
說明書	Product Datasheet Protocol
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