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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Sphingosine 1-Phosphate Receptor 1 (extracellular) Antibody品牌 |
Leading Biology | 貨號 |
APR00489G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Sphingosine 1-Phosphate Receptor 1 (extracellular) Antibody.
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分子量 |
42811 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點 |
Peptide SDYVNYDIIVRHYN(C), corresponding to amino acid residues 17-30 of human Sphingosine 1-Phosphate Receptor 1 (S1PR1), (Accession P21453). Extracellular, N-terminus.
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基因ID |
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UniProt ID |
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總結(jié) |
Lysophospholipids constitute a group of important lipid mediators; lysophosphatidic acid (LPA) a glycerolysophospholipid and sphingosine 1-phosphate (SIP), a lysosphingolipid. Sphingosine 1-phosphate is a bioactive lipid derived from metabolism of sphingomyelin1. Sphingosine 1-phosphate is implicated in the regulation of many cellular functions including proliferation, apoptosis, survival, adhesion, differentiation, and migration2. Sphingosine 1-phosphate exerts its activity through five distinct G-protein-coupled receptors, (also named endothelial differentiation gene receptors - EDG); S1PR1 (EDG-1), S1PR2 (EDG-5), S1PR3 (EDG-3), S1PR4 (EDG-6), and S1PR5 (EDG-8)3. Sphingosine 1-Phosphate Receptor 1 (S1PR1) is ubiquitously expressed. S1PR1 mRNA is detected in the brain, heart, spleen, liver, lung, thymus, kidney, skeletal muscle and lymphoid tissues4.Knockout of the gene encoding S1PR1 is lethal and therefore makes in vivo studies difficult 5. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of the human Sphingosine 1-Phosphate Receptor 1. Anti-Sphingosine 1-Phosphate Receptor 1 (extracellular) antibody, (#AG1015) can be used in western blot analysis, immunohistochemistry and immunocytochemistry applications. It has been designed to recognize Sphingosine 1-Phosphate Receptor 1 from human, rat and mouse samples.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, ICC
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稀釋方法 |
WB~~1:200-1:2000
IHC~~1:100
ICC~~1:50
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圖像 |
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說明書 |
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數(shù)量 |
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