品牌 |
Leading Biology | 貨號(hào) |
APR06894G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality XKR8 Antibody.
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分子量 |
Predicted: 43 kDa Observed: 47 kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
XKR8; XKR8 antibody is human reactive. At least two isoforms are known to exist; this antibody will detect both isoforms.
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亞型 |
IgG
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通用名 |
XRG8
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基因ID |
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UniProt ID |
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功能 |
Promotes phosphatidylserine exposure on apoptotic cell surface, possibly by mediating phospholipid scrambling. Phosphatidylserine is a specific marker only present at the surface of apoptotic cells and acts as a specific signal for engulfment. Has no effect on calcium-induced exposure of phosphatidylserine. Activated upon caspase cleavage, suggesting that it does not act prior the onset of apoptosis.
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總結(jié) |
The XK Kell blood group complex subunit-related family member 8 (XKR8) is a member of a family of proteins that promote the phagocytosis of dying cells by altering the phospholipid distribution of the plasma membrane (1). XKR8 is thought to be a “scramblase”, an enzyme that eliminates the asymmetry of phospholipid distribution in the plasma membrane. In apoptotic cells, XKR8 promotes the cell-surface exposure of phosphatidylserine (PtdSer) which serves as a signal for phagocytosis (1,2).
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, IF, E
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圖像 |
Western blot analysis of XKR8 in human stomach tissue lysate with XKR8 antibody at 1 μg/ml. Immunohistochemistry of XKR8 in human stomach tissue with XKR8 antibody at 5 μg/ml. Immunofluorescence of XKR8 in human stomach tissue with XKR8 antibody at 20 μg/ml. |
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說(shuō)明書 |
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數(shù)量 |
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