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當(dāng)前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > OASL Antibody

OASL Antibody

貨號 貨期 規(guī)格 / 價格 詢價
APR06879G 0.1 mg / ¥6950

OASL Antibody

品牌

Leading Biology

貨號

APR06879G

產(chǎn)品分類

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality OASL Antibody.

分子量

Predicted: 57 kDa Observed: 65 kDa

細胞定位

Antigen Cellular Localization: Isoform p56: Nucleus, nucleolus. Cytoplasm.

宿主

Rabbit

種屬反應(yīng)性

Human, Mouse, Rat

靶點

OASL; OASL antibody is human, mouse and rat reactive.

亞型

IgG

通用名

TRIP14

基因ID

UniProt ID

功能

Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity against encephalomyocarditis virus (EMCV) and hepatitis C virus (HCV) via an alternative antiviral pathway independent of RNase L.

總結(jié)

OASL (2'-5'-oligoadenylate synthetase-like), also known as p59OASL or TRIP14 (thyroid receptor-interacting protein 14), is a 514 amino acid protein that exists as two alternatively spliced isoforms, designated p56 and p30, and contains two ubiquitin-like domains (1). It is widely expressed in a variety of tissues and interacts with the ligand binding domain of the thyroid receptor (TR) and is able to bind double-stranded RNA and DNA, possibly playing a role in RNA degradation and the overall inhibition of protein synthesis (2-3). Methyl CpG-binding protein 1 (MBD1), which functions as a transcriptional repressor, was identified as a strong p59 OASL interactor (4).

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IF, ICC, E

圖像

Western blot analysis of OASL in mouse bladder tissue lysate with OASL antibody at 1 μg/ml.

Immunocytochemistry of OASL1 in HepG2 cells with OASL1 antibody at 2.5 μg/mL.

Immunofluorescence of OASL1 in HepG2 cells with OASL1 antibody at 20 μg/mL.

說明書

數(shù)量

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