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全部產(chǎn)品分類(lèi)
品牌 |
Leading Biology | 貨號(hào) |
APR06779G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ATG2B Antibody.
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分子量 |
229 kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Preautophagosomal structure membrane; Peripheral membrane protein. Lipid droplet
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
ATG2B; ATG2B antibody is predicted to not cross-react with other ATG2A.
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亞型 |
IgG
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通用名 |
C14orf103
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基因ID |
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UniProt ID |
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功能 |
Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.
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總結(jié) |
ATG2B Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. Another member of the autophagy family of proteins is ATG2B, one of two homologs of ATG2 that is essential for autophagosome formation and important for regulation of size and distribution of lipid droplets. Relatively high rates of ATG2B mutations were observed in gastric and colorectal carcinomas, suggesting that deregulating the autophagy process may contribute to cancer development.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IF, E
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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