品牌 |
Leading Biology | 貨號(hào) |
APR06693G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality ZFP219 Antibody.
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分子量 |
76877 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus.
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點(diǎn) |
ZNF219; At least two isoforms of ZFP219 are known to exist; this antibody will recognize both.
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亞型 |
IgG
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基因ID |
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UniProt ID |
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功能 |
May be involved in transcriptional regulation.
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總結(jié) |
ZFP219 Antibody: ZFP219 is a developmentally regulated member of the Kruppel-like zinc finger gene family that is thought to function as a transcriptional repressor. Yeast two-hybrid screening showed association with Sox9, a transcription factor that is essential for chondrogenesis. ZFP219 is specifically expressed in the developing limb buds and colocalizes with Sox9 in the nucleus. Knockdown of ZFP219 expression decreased Sox9-induced mRNA expression, and a dominant-negative mutant of ZFP219 inhibited Bmp2-induced chondrocyte differentiation, suggesting that ZFP219 plays an important role as a transcriptional partner of Sox9 in the regulation of chondrocyte differentiation.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P, IF, E
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圖像 |
Western blot analysis of ZFP219 in mouse brain tissue lysate with ZFP219 antibody at (A) 1 and (B) 2 μg/mL. Immunohistochemistry of ZFP219 in mouse brain tissue with ZFP219 antibody at 5 μg/mL. Immunofluorescence of ZFP219 in mouse brain tissue with ZFP219 antibody at 20 μg/mL. |
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說(shuō)明書(shū) |
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數(shù)量 |
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