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當(dāng)前位置:首頁 > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > SYNPO2 Antibody

SYNPO2 Antibody

貨號 貨期 規(guī)格 / 價格 詢價
APR06682G 0.1 mg / ¥6950

SYNPO2 Antibody

品牌

Leading Biology

貨號

APR06682G

產(chǎn)品分類

Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality SYNPO2 Antibody.

分子量

117514 Da

細(xì)胞定位

Antigen Cellular Localization: Nucleus. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion Localizes to the Z-disk in mature striated muscle. The nuclear export is XPO1-dependent (By similarity). Localized in a fiber- like pattern. partly overlapping with filamentous actin {ECO:0000250, ECO:0000269|PubMed:18371299}

宿主

Rabbit

種屬反應(yīng)性

Human, Mouse

靶點(diǎn)

SYNPO2;

亞型

IgG

基因ID

UniProt ID

功能

Has an actin-binding and actin-bundling activity.

總結(jié)

SYNPO2 Antibody: SYNPO2 was initially identified as myopodin, a member of the synaptopodin family that contains one PPXY motif and multiple PXXP motifs. It colocalizes with alpha-actinin and is found at the Z-disc and during stress conditions will translocate to the nucleus, suggesting that it is part of signaling pathways in addition to its function as a structural protein. SYNPO2 has been shown to bind to calmodulin, alpha-actinin, and smooth muscle myosin and will stimulate actin polymerization in a calmodulin dependent manner, consistent with its proposed role in organizing the cytoskeleton. While deletion of SYNPO2 has been reported to be highly correlated with the invasiveness of prostate cancers, other reports suggest that down-regulation of SYNPO2 reduces the invasiveness and motility of prostate cancer cells.

儲存條件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用

WB, IHC-P, IF, E

圖像

Western blot analysis of SYNPO2 in human skeletal muscle tissue lysate with SYNPO2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.

Immunohistochemistry of SYNPO2 in mouse skeletal muscle tissue with SYNPO2 antibody at 5 μg/mL.

Immunofluorescence of SYNPO2 in mouse skeletal muscle tissue with SYNPO2 antibody at 20 μg/mL.

說明書

數(shù)量

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