品牌 |
Leading Biology | 貨號 |
APR06288G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality PERP Antibody.
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分子量 |
Predicted: 27 kDa Observed: 30 kDa
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細胞定位 |
Antigen Cellular Localization:
Cell junction, desmosome. Cell membrane; Multi-pass membrane protein. Note=Associated with desmosomes
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點 |
Perp;
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亞型 |
IgG
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通用名 |
Krtcap1
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基因ID |
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UniProt ID |
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功能 |
Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway.
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總結(jié) |
PERP Antibody: The p53 tumor-suppressor gene integrates numerous signals that control cell life and death. Several novel molecules involved in p53 network, including Chk2, p53R2, p53AIP1, Noxa, PIDD, PID/MTA2, MTBP and PERP, were identified and their genes were cloned recently. PERP, also termed PIGPC1 and THW, is a plasma membrane protein. p53 binds to the promoter of PERP and transcriptionally activates PERP gene then the translated PERP protein mediates the p53 induced apoptosis. The expression of PERP causes cell death. PERP is a mediator of p53 induced apoptosis. PERP has sequence similarity to PMP-22/gas3 and is a new member of the PMP-22/gas3 family.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, ICC, E
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圖像 |
Western blot analysis of PERP expression in A431 whole cell lysates in the absence (A) and presence (B) of blocking peptide with PERP antibody at 1 μg/mL. Immunocytochemistry of PERP in A431 cells with PERP antibody at 10 μg/mL. |
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說明書 |
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數(shù)量 |
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