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全部產(chǎn)品分類(lèi)
品牌 |
Leading Biology | 貨號(hào) |
APR00492G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality P2X3 (extracellular) Antibody.
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分子量 |
44392 Da
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Mouse, Rat
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靶點(diǎn) |
Peptide (C)KGFGRYANRVMDVSD, corresponding to amino acid residues 65-79 of rat P2X3 Receptor (Accession P49654). Extracellular.
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基因ID |
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UniProt ID |
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總結(jié) |
The P2X3 receptor belongs to the ligand-gated ion channel P2X family, that consists of seven receptor subtypes named P2X1-P2X7 and is activated by extracellular ATP 1-3.All P2X subunits, with the exception of P2X6, can assemble to form homomeric or heteromeric functional channels4,5. The different P2X receptors show distinct expression patterns. P2X1-6 has been found in the central and peripheral nervous system, while the P2X7 receptor is predominantly found in cells of the immune system. The P2X3 receptor is highly expressed on nociceptive sensory neurons in dorsal root ganglia (DRG) as a homomer or as a heteromer (P2X3/P2X2). ATP released from damaged cells activates the P2X3 receptor to initiate nociceptive signals6,7. Involvement of ATP in the mechanism of chronic pain has been also suggested7,8. P2X3 receptor is now becoming a possible target for the development of pain therapeutics.Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of rat P2X3 receptor. Anti-P2X3 Receptor (extracellular) antibody (#AG1060) can be used in western blot immunohistochemical and immunocytochemical applications. It has been designed to recognize P2X3 receptor from rat, mouse, and human samples.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, LCI
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稀釋方法 |
WB~~1:200-1:2000
ICC~~1:50
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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