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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR00387G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality P-glycoprotein Antibody.
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分子量 |
141479 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat
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靶點(diǎn) |
P-glycoprotein
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亞型 |
Rabbit Ig
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通用名 |
MDR1, PGY1
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基因ID |
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UniProt ID |
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功能 |
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells.
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總結(jié) |
P-gp, also called MDR1 or ABCB1, is a glycoprotein that in humans is encoded by the ABCB1 gene. P-gp is a well-characterized ABC-transporter (which transports a wide variety of xenobiotics across extra- and intracellular membranes). It is an ATP-dependent drug efflux pump with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein functions in the kidneys, liver, blood–brain barrier and the intestinal epithelium.
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形式 |
Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
IHC, IHC-F
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圖像 |
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說(shuō)明書(shū) |
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數(shù)量 |
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