品牌 |
Leading Biology |
貨號 |
APR00709G |
產(chǎn)品分類 |
Polyclonal Antibodies |
研究領域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Fbxw7 antibody - middle region.
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分子量 |
70kDa
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細胞定位 |
Antigen Cellular Localization:
Nucleus, nucleoplasm
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宿主 |
Rabbit
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種屬反應性 |
Human, Mouse, Rat, Rabbit, Zebrafish, Horse, Bovine, Dog
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基因ID |
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UniProt ID |
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功能 |
Substrate recognition component of an SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC
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圖像 |
WB Suggested Anti-Fbxw7 Antibody Titration: 0.2-1 μg/ml
Positive Control: Mouse Lung
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說明書 |
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數(shù)量 |
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