品牌 |
Leading Biology | 貨號 |
APR00639G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Pthlh antibody - middle region.
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分子量 |
16kDa
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Secreted
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宿主 |
Rabbit
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種屬反應性 |
Human, Mouse, Rat, Goat, Sheep, Horse, Bovine, Dog
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通用名 |
Pthrp
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UniProt ID |
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功能 |
Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC
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圖像 |
WB Suggested Anti-Pthlh Antibody Titration: 1 μg/mlPositive Control: Mouse Brain lysate Immunohistochemistry with Lung tissue at an antibody concentration of 5μg/ml using anti-Pthlh antibody (AI1577) |
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說明書 |
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數(shù)量 |
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