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Phospho-Ser33,37 β-Catenin Antibody

APR03387G Product Datasheet Protocol

貨號	貨期	規(guī)格 / 價格	詢價
APR03387G		100 μl / ￥5450

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安諾倫（北京）生物科技有限公司

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Phospho-Ser33,37 β-Catenin Antibody

品牌	Leading Biology	貨號	APR03387G
產品分類	Polyclonal Antibodies	研究領域
產品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-Ser33,37 β-Catenin Antibody.
分子量	83 KDa
宿主	Rabbit
種屬反應性	Human
靶點	Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser33/37 conjugated to KLH.
基因ID	1499
UniProt ID	P35222
總結	β-catenin is a central component of the cadherin cell adhesion complex and plays an essential role in neural development in the Wingless/Wnt signaling pathway (Ding and Dale, 2002; Polakis, 2000). The role of β-catenin in these processes is thought regulated by the sequential phosphorylation of Ser29 Ser33, Ser37 and Thr41 by glycogen synthase kinase 3β (GSK3β) (Liu et al., 2002). This hyperphosphorylation promotes the ubiquitylation and targeted destruction of β-catenin. Mutations in components of this phosphorylation regulated process that prevent β-catenin hyperphosphorylation by GSK3β are trongly associated with cancers (Wang et al., 2003; Polakis, 2000; Liu et al., 2002).
儲存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應用	WB
稀釋方法	WB~~ 1:1000
圖像	Western blot of human embryonic kidney cell (HEK) lysate showing specific immunolabeling of the ~83k β-catenin phosphorylated at Ser33 and Ser37 (Upper Panel) and a pan β-catenin (Lower Panel). Control is a standard HEK cell lysate. GSK3 is a HEK cell lysate with glycogen synthase kinase 3β knocked down by SiRNA.
說明書	Product Datasheet Protocol
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