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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Metabotropic Glutamate Receptor 5/1a Antibody

Metabotropic Glutamate Receptor 5/1a Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR03384G 100 μl / ￥5450

Metabotropic Glutamate Receptor 5/1a Antibody

品牌

 Leading Biology

貨號(hào)

 APR03384G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Metabotropic Glutamate Receptor 5/1a Antibody.

分子量
125/250 KDa

宿主
Rabbit

種屬反應(yīng)性
Rat

靶點(diǎn)
Synthetic peptide corresponding to amino acid residues from the C-terminal region conjugated to KLH.

基因ID

UniProt ID

總結(jié)
The metabotropic glutamate receptors (mGluRs) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. They are implicated in many forms of neural plasticity as well as learning and memory and drug abuse (Bhattacharya et al., 2004; Francesconi et al., 2004; Wilson and Nicoll, 2001). Group I metabotropic glutamate receptors (consisting of mGluR1 and mGluR5) are G-protein-coupled neurotransmitter receptors that are localized in the perisynaptic region of the postsynaptic membrane. When activated, Group I mGluRs lead to stimulation of phospholipase and activation of Protein Kinase C. In contrast, activation of Group II metabotropic receptors (mGluR2 and mGluR3) leads to inhibition of adenylate cyclase. The mGluR1 receptor may also be critically involved in limiting the deleterious effects of excitotoxicity (Blaabjerg et al., 2003). In contrast, the mGluR5 receptor appears to be essential for late phase LTP in area CA1 of the hippocampus (Francesconi et al., 2004).

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, FC

稀釋方法
FC~~1:500 WB~~ 1:1000

圖像

Flow cytometric analysis of PC-12 cells using Park7 (DJ-1) Antibody(green, APR03384G) compared to an isotype control of rabbit IgG(blue). APR03384G was diluted at 1:500 dilution. An Alexa Fluor? 488 goat anti-rabbit lgG at 1:400 dilution was used as the secondary antibody.

Western blot of 10 ug of HEK 293 cells expressing mGluR1a and mGluR5 showing the specific immunolabeling of the ~125k monomer and the ~250k dimers of mGluR1a and mGluR5.

說(shuō)明書(shū)

數(shù)量

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