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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > KNG1 / Kininogen / Bradykinin Antibody (aa1-416)

KNG1 / Kininogen / Bradykinin Antibody (aa1-416)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR03158G 50 μl / ￥4950

KNG1 / Kininogen / Bradykinin Antibody (aa1-416)

品牌

 Leading Biology

貨號(hào)

 APR03158G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality KNG1 / Kininogen / Bradykinin Antibody (aa1-416).

分子量
72kDa

細(xì)胞定位
Antigen Cellular Localization: Secreted, extracellular space.

宿主
Rabbit

種屬反應(yīng)性
Human

靶點(diǎn)
Human Kininogen / Bradykinin

通用名
BDK, KNG

基因ID

UniProt ID

功能
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting.

總結(jié)
(1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects: (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation and causes (4E1) increase in vascular permeability, (4E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (4F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action); (5) LMW-kininogen inhibits the aggregation of thrombocytes; (6) LMW- kininogen is in contrast to HMW-kininogen not involved in blood clotting.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC-P, ICC

稀釋方法
ICC (1:100-1:1000), IHC-P (7.5 μg/ml), WB (1:500-1:3000)

圖像

Sample (30 ug of whole cell lysate).

Immunofluorescence of paraformaldehyde-fixed HeLa using Kininogen-1 antibody at 1:200 dilution.

Anti-KNG1 / Kininogen / Bradykinin antibody IHC staining of human small intestine.

說(shuō)明書

數(shù)量

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