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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > RIPK1 / RIP Antibody (N-Terminus)

RIPK1 / RIP Antibody (N-Terminus)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢(xún)價(jià)
APR02641G 50 μg / ￥4950

RIPK1 / RIP Antibody (N-Terminus)

品牌

 Leading Biology

貨號(hào)

 APR02641G

產(chǎn)品分類(lèi)

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality RIPK1 / RIP Antibody (N-Terminus).

分子量
76kDa

細(xì)胞定位
Antigen Cellular Localization: Cytoplasm. Cell membrane.

宿主
Rabbit

種屬反應(yīng)性
Human, Mouse, Rat

靶點(diǎn)
Human RIPK1

通用名
RIP, RIP1

基因ID

UniProt ID

功能
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

總結(jié)
Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC-P, IF, E

稀釋方法
IHC-P (5 μg/ml), WB (1-2 μg/ml),

圖像

Immunofluorescence of RIPK1 in Mouse Kidney cells with RIPK1 antibody at 20 ug/ml.

Western blot of RIPK1 in rat kidney tissue lysate with RIPK1 antibody at 1 ug/ml.

Anti-RIPK1 /RIP antibody IHC of human kidney.

說(shuō)明書(shū)

數(shù)量

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