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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > YES1 / c-Yes Antibody

YES1 / c-Yes Antibody

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APR02615G 50 μl / ￥4950

YES1 / c-Yes Antibody

品牌

 Leading Biology

貨號(hào)

 APR02615G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality YES1 / c-Yes Antibody.

分子量
61kDa

細(xì)胞定位
Antigen Cellular Localization: Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytosol Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway

宿主
Rabbit

種屬反應(yīng)性
Human, Mouse

靶點(diǎn)
Human and mouse c-Yes. Predicted cross-reactivity based on amino acid sequence homology: rat (88%), bovine (89%), dogs (98%), zebrafish (95%).

通用名
YES

基因ID

UniProt ID

功能
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

總結(jié)
Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, IHC-P, IF, ICC

稀釋方法
IF (1:100-1:200), IHC-P (10 μg/ml), WB (1:500-1:3000)

圖像

Immunofluorescence of methanol-fixed HeLa, using c-Yes antibody at 1:200 dilution.

Sample (30 ug of whole cell lysate). A: A431. 7.5% SDS PAGE. YES1 antibody diluted at 1:1000.

Sample (30 ug of whole cell lysate). A: NIH-3T3. 7.5% SDS PAGE. YES1 antibody diluted at 1:1000.

說(shuō)明書(shū)

數(shù)量

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