全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR02587G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality LIME1 / LIME Antibody (aa141-295).
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分子量 |
31kDa
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細(xì)胞定位 |
Antigen Cellular Localization:
Cell membrane; Single-pass type III membrane protein. Note=Present in lipid rafts Recruited to the immunological synapse upon conjugation of T-cell with antigen-presenting cell
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
Reacts with the cytoplasmic domain of LIME, a 31 kD Lck-interacting transmembrane adaptor expressed by T cells.
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通用名 |
LIME
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基因ID |
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UniProt ID |
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功能 |
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
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總結(jié) |
Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T- cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC-P
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稀釋方法 |
IHC-P (10 μg/ml)
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圖像 |
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說明書 |
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數(shù)量 |
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