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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > NFKBIA / IKB Alpha / IKBA Antibody (C-Terminus)品牌 |
Leading Biology | 貨號 |
APR02424G |
產品分類 |
Polyclonal Antibodies | 研究領域 |
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產品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality NFKBIA / IKB Alpha / IKBA Antibody (C-Terminus).
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分子量 |
36kDa
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細胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export.
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宿主 |
Rabbit
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種屬反應性 |
Human, Mouse, Rat
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靶點 |
Peptide mapping to the carboxy terminus of human IkB-alpha
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通用名 |
IKBA, MAD3, NFKBI
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基因ID |
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UniProt ID |
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功能 |
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
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總結 |
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應用 |
WB, IHC-P, IP
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稀釋方法 |
IHC-P (1:50)
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圖像 |
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說明書 |
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數(shù)量 |
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