CDK12 / CRKRS Antibody (C-Terminus)

APR02059G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR02059G		50 μg / ￥4950

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安諾倫（北京）生物科技有限公司

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CDK12 / CRKRS Antibody (C-Terminus)

品牌	Leading Biology	貨號(hào)	APR02059G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality CDK12 / CRKRS Antibody (C-Terminus).
分子量	164kDa
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Nucleus speckle. Note=Colocalized with nuclear speckles throughout interphase
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rabbit, Hamster, Monkey, Dog
靶點(diǎn)	Human CDK12 / CRKRS. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except POMT1 (37%).
通用名	CRK7, CRKRS, KIAA0904
基因ID	51755
UniProt ID	Q9NYV4
功能	Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
總結(jié)	Cyclin-dependent kinase that phosphorylates the C- terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors.
形式	Liquid
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	IHC-P
稀釋方法	IHC-P (4-5 μg/ml)
圖像	Anti-CDK12 / CRKRS antibody IHC of human Skin, Melanoma. Anti-CDK12 / CRKRS antibody APR02059G IHC of human spleen.
說(shuō)明書(shū)	Product Datasheet Protocol
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