Phospho-HDAC2-S394 Antibody

APR00480G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢(xún)價(jià)
APR00480G		0.1 mg / ￥4950

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Phospho-HDAC2-S394 Antibody

品牌	Leading Biology	貨號(hào)	APR00480G
產(chǎn)品分類(lèi)	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Phospho-HDAC2-S394 Antibody.
分子量	55364 Da
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Cytoplasm
宿主	Rabbit
種屬反應(yīng)性	Human, Mouse, Rat
靶點(diǎn)	The antibody was affinity-purified from rabbit antiserum using epitope-specific phosphopeptide column, and the antibody against non-phosphopeptide was removed using non-phosphopeptide column corresponding to the phosphorylation site.
亞型	Rabbit IgG
基因ID	3066
UniProt ID	Q92769
功能	Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A.
總結(jié)	This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants.
形式	Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB, IHC, IF
稀釋方法	WB~~1:500~1:1000 IHC~~1:50~1:100 IF~~1:100~200
圖像	Western blot analysis of extracts from HT-29 cells untreated or treated with UV (20min), using HDAC2 Antibody (S394) (Lane 1 and 2) and Phospho-HDAC2-S394 Antibody (APR00480G, Lane 3 and 4). Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Phospho-HDAC2-S394 Antibody (APR00480G). Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear staining using Phospho-HDAC2-S394 Antibody (APR00480G).
說(shuō)明書(shū)	Product Datasheet Protocol
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