FBXO11 Antibody (N-term)

APR06954G Product Datasheet Protocol

貨號(hào)	貨期	規(guī)格 / 價(jià)格	詢價(jià)
APR06954G		100 μl / ￥4950

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安諾倫（北京）生物科技有限公司

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Tel: 010-56256916
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FBXO11 Antibody (N-term)

品牌	Leading Biology	貨號(hào)	APR06954G
產(chǎn)品分類	Polyclonal Antibodies	研究領(lǐng)域
產(chǎn)品概述	We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality FBXO11 Antibody (N-term).
分子量	H=104,23,107 KDa
細(xì)胞定位	Antigen Cellular Localization: Nucleus. Chromosome.
宿主	Rabbit
種屬反應(yīng)性	Human
免疫原	55-83 aa
靶點(diǎn)	This FBXO11 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 55-83 amino acids from the N-terminal region of human FBXO11.
通用名	FBX11, PRMT9, VIT1
基因ID	80204
UniProt ID	Q86XK2
功能	Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF- beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53.
總結(jié)	This gene encodes a member of the F-box protein familywhich is characterized by an approximately 40 amino acid motif, theF-box. The F-box proteins constitute one of the four subunits ofubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box),which function in phosphorylation-dependent ubiquitination. TheF-box proteins are divided into 3 classes: Fbws containing WD-40domains, Fbls containing leucine-rich repeats, and Fbxs containingeither different protein-protein interaction modules or norecognizable motifs. The protein encoded by this gene belongs tothe Fbxs class. It can function as an arginine methyltransferasethat symmetrically dimethylates arginine residues, and it acts asan adaptor protein to mediate the neddylation of p53, which leadsto the suppression of p53 function. This gene is known to bedown-regulated in melanocytes from patients with vitiligo, a skindisorder that results in depigmentation. Polymorphisms in this geneare associated with chronic otitis media with effusion andrecurrent otitis media (COME/ROM), a hearing loss disorder, and theknockout of the homologous mouse gene results in the deaf mousemutant Jeff (Jf), a single gene model of otitis media.Alternatively spliced transcript variants encoding distinctisoforms have been identified for this gene.
儲(chǔ)存條件	Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
應(yīng)用	WB
稀釋方法	WB~~1:1000
圖像	All lanes : Anti-FBXO11 Antibody (N-term) at 1:1000 dilution Lane 1: MDA-MB-453 whole cell lysate Lane 2: 293T/17 whole cell lysate Lane 3: Hela whole cell lysate Lysates/proteins at 20 μg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 104 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
說(shuō)明書	Product Datasheet Protocol
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