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當(dāng)前位置：首頁(yè) > 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Goat Anti-CCAR2 / DBC1 Antibody (internal region)

Goat Anti-CCAR2 / DBC1 Antibody (internal region)

貨號(hào) 貨期 規(guī)格 / 價(jià)格 詢價(jià)
APG00966G 100 μg / ￥4950

Goat Anti-CCAR2 / DBC1 Antibody (internal region)

品牌

 Leading Biology

貨號(hào)

 APG00966G

產(chǎn)品分類

 Polyclonal Antibodies

研究領(lǐng)域

產(chǎn)品概述
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality Goat Anti-CCAR2 / DBC1 Antibody (internal region).

分子量
102902 Da

細(xì)胞定位
Antigen Cellular Localization: Nucleus. Note=Recruited to chromatin, post-UV irradiation

宿主
Goat

種屬反應(yīng)性
Human

通用名
DBC1, KIAA1967

基因ID

UniProt ID

功能
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by preventing its ubiquitination and subsequent degradation.

形式
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

儲(chǔ)存條件
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

應(yīng)用
WB, E

圖像

APG00966G (0.5 μg/ml) staining of HEK293 (A) and MCF7 (B) nuclear lysates (35 μg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

說(shuō)明書

數(shù)量

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