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> 抗原抗體、ELISA、WB > 一抗 > Polyclonal Antibodies > Goat Anti-Munc13-4 / UNC13D (Internal) Antibody品牌 |
Leading Biology | 貨號(hào) |
APG00206G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality Goat Anti-Munc13-4 / UNC13D (Internal) Antibody.
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分子量 |
123282 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Membrane; Peripheral membrane protein. Late endosome. Recycling endosome. Lysosome Note=Colocalizes with cytotoxic granules at the plasma membrane Localizes to endosomal exocytic vesicles
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宿主 |
Goat
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種屬反應(yīng)性 |
Human, Mouse
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亞型 |
IgG
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基因ID |
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UniProt ID |
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功能 |
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
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總結(jié) |
This gene encodes a protein that is a member of the UNC13 family, containing similar domain structure as other family members but lacking an N-terminal phorbol ester-binding C1 domain present in other Munc13 proteins. The protein appears to play a role in vesicle maturation during exocytosis and is involved in regulation of cytolytic granules secretion. Mutations in this gene are associated with familial hemophagocytic lymphohistiocytosis type 3, a genetically heterogeneous, rare autosomal recessive disorder.
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形式 |
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, E
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圖像 |
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說明書 |
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數(shù)量 |
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