品牌 |
Leading Biology | 貨號(hào) |
APR00361G |
產(chǎn)品分類(lèi) |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality OCT4 (OCT3) Antibody.
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分子量 |
38571 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern
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宿主 |
Rabbit
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靶點(diǎn) |
Oct4/Oct3
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亞型 |
Rabbit IgG
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通用名 |
OCT3, OCT4, OTF3
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基因ID |
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UniProt ID |
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功能 |
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency.
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總結(jié) |
Oct-4 (POU5F1) is a transcription factor highly expressed in undifferentiated embryonic stem cells and embryonic germ cells. A network of key factors that includes Oct-4, Nanog, and Sox2 is necessary for the maintenance of pluripotent potential, and downregulation of Oct-4 has been shown to trigger cell differentiation. Research studies have demonstrated that Oct-4 is a useful germ cell tumor marker. Oct-4 exists as two splice variants, Oct-4A and Oct-4B. Recent studies have suggested that the Oct-4A isoform has the ability to confer and sustain pluripotency, while Oct-4B may exist in some somatic, non-pluripotent cells.
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形式 |
Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IF
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說(shuō)明書(shū) |
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數(shù)量 |
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選擇 | 品牌 | 貨號(hào) | 產(chǎn)品名稱(chēng) | 規(guī)格 | 分類(lèi) | 研究領(lǐng)域 | 說(shuō)明書(shū) | 數(shù)量 | 目錄價(jià) | |
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