全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號 |
APR00018G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality CD40 Antibody.
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分子量 |
30619 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Isoform I: Cell membrane; Single-pass type I membrane protein
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human, Mouse, Rat, Monkey, Pig
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靶點(diǎn) |
CD40
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亞型 |
Rabbit IgG
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通用名 |
TNFRSF5
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基因ID |
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UniProt ID |
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功能 |
Receptor for TNFSF5/CD40LG. Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion.
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總結(jié) |
CD40 is a type I membrane protein found on the surface of B cells and primary carcinomas. It belongs to the TNF-R family. CD40 serves as the receptor for CD40 ligand (CD40L), a cytokine expressed on the cell surface of T cells. CD40 plays a critical role in B cell proliferation, antibody class switching, modulation of apoptosis in the germinal center thro μgh interaction with T cells expressing CD40L, and activation of CD4+ T cells. In non-hemopoitic cells such as epidermal basal cells, CD40 ligation serves as the signal for inhibition of cell growth and induction of differentiation. The cytoplasmic domain of CD40 interacts with TRAF6, a TNFR associated factor homolog that mediates signaling from CD40. Ligation of CD40 with its ligand preferentially induces stress-activated protein kinases in B lymphocytes.
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形式 |
Liquid
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儲存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB
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圖像 |
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說明書 |
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數(shù)量 |
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