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全部產(chǎn)品分類
品牌 |
Leading Biology | 貨號(hào) |
APR00304G |
產(chǎn)品分類 |
Polyclonal Antibodies | 研究領(lǐng)域 |
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產(chǎn)品概述 |
We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format.
We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team.
This product is a high quality HDAC8 Antibody.
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分子量 |
41758 Da
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細(xì)胞定位 |
Antigen Cellular Localization:
Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation
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宿主 |
Rabbit
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種屬反應(yīng)性 |
Human
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靶點(diǎn) |
HDAC8
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亞型 |
Rabbit IgG
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通用名 |
HDACL1
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基因ID |
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UniProt ID |
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功能 |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.
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總結(jié) |
Mammalian HDAC-8, isolated from human kidney, is a member of the histone deacetylase family. HDAC-8 shares homology with other HDACs in the family, but has different tissue distribution. HDAC-8 is localized to the nucleus and plays a role in the tissue development as well as cancer etiology.
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形式 |
Liquid
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儲(chǔ)存條件 |
Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
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應(yīng)用 |
WB, IHC, IP
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圖像 |
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說(shuō)明書 |
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數(shù)量 |
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